Technology Guide

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DDN’s Technology Guides provide the information scientists need to get started with new instruments, methods, and services.

Each Technology Guide includes the following content pieces:

  • An introduction to the technology, including the top factors that new customers should consider when introducing your technology into their labs
  • A graphical overview of the technique
  • A table listing the key resources and products
  • A troubleshooting Q&A article based on an interview with a product expert

2024 Multisponsored Topics

Mass Spectrometry

A Technology Guide for TMT-based Proteomic Analysis

Tandem mass tags (TMT) are powerful tools for proteomics that rely on isobaric chemical tags with different mass-to-charge ratios for multiplexed sample analysis. This technique enables concurrent comparison of multiple conditions, providing insights into differential protein expression, post-translational modifications, and protein interactions within complex biological samples. This Technology Guide will explore the fundamental principles and applications of TMT and discuss the considerations and best practices for TMT experiments.

Genomics and Sequencing

A Technology Guide for Metagenomics

Microbiome studies rely on 16S ribosomal RNA sequencing to identify microbes in a particular population. But sometimes knowing the identity of a microbe is not enough. That’s where shotgun metagenomics steps in. Metagenomics reveals the genomic information of all organisms in a sample, giving scientists insight on how each organism functions within the group. This Technology Guide will explain how shotgun metagenomics works, introduce best practices, and provide expert advice on starting metagenomics studies.

Proteomics

A Technology Guide for Bottom-up Proteomics

Bottom-up proteomics helps scientists to identify proteins and characterize their amino acid sequences and post-translational modifications. The approach involves proteolytic digestion of proteins prior to mass spectrometry analysis. It has been instrumental in uncovering biomarkers and elucidating protein interactions. This Technology Guide will explore the principles, techniques, and applications of bottom-up proteomics.

3D Cell Culture

A Technology Guide for 3D Cell Culture

Cells exist in living organisms in complicated multidimensional structures occupied by other cell types, supported by layers of extracellular matrix, and vascularized by vessels. 3D cell culture offers the opportunity to model these dynamic in vivo architectures more closely, but for many scientists new to this area of research, getting started is not easy. This Technology Guide will break down the key considerations for starting a 3D cell culture experiment, introduce the tools and reagents necessary for success, and provide expert troubleshooting advice.

CRISPR

A Technology Guide for CRISPR-based Screens

CRISPR-based screening takes advantage of the CRISPR/Cas9 gene-editing system to identify genes that are critical for disease processes, potentially leading to the development of new therapeutic strategies. This Technology Guide will explain how CRISPR-based screens work and provide guidance on how to choose and implement the best CRISPR screen to meet experimental needs.